sio۲/h۲so۴: an efficient catalytic system for solvent-free ۱, ۵-benzodiazepines synthesis
نویسندگان
چکیده
background 1, 5-benzodiazepines have been investigated extensively by organic chemists due to their medicinal and pharmacological properties. these compounds are synthesized by condensation of o-phenylenediamines with carbonyl compounds in the presence of acid catalysts. objectives during our studies on the application of silica resin with acid functional moieties, we found that sio2/h2so4 mixture is a simple and efficient catalyst for this method under microwave irradiation. materials and methods the reaction was carried out simply by grinding sio2/h2so4 mixture with o-phenylenediamine, and ketone in the mortar; then the mixture was poured out into a sealed flask. subsequently, it was irradiated in a microwave oven. results in this method a series of cyclic and acyclic ketones underwent above conversion to form corresponding 1, 5-benzodiazepines. conclusions in conclusion, this method is a simple, rapid, and high yielding reaction (78–95%).
منابع مشابه
SiO2/H2SO4: An Efficient Catalytic System for Solvent-free 1, 5-benzodiazepines Synthesis
BACKGROUND 1, 5-Benzodiazepines have been investigated extensively by organic chemists due to their medicinal and pharmacological properties. These compounds are synthesized by condensation of o-phenylenediamines with carbonyl compounds in the presence of acid catalysts. OBJECTIVES During our studies on the application of silica resin with acid functional moieties, we found that SiO2/H2SO4 mi...
متن کاملZnO nanoparticles as an Efficient and Reusable Catalyst for Synthesis of Quinoxaline under Solvent Free Condition
1,2-Diketones have been reacted in one-pot method with 1,2-diamines at room temperature with ZnO nanoparticles as a catalyst. ZnO nanoparticles as an available and reusable catalyst is used for the synthesis of Quinoxalinein improved yields.
متن کاملPolymer/HIO4 : An efficient catalyst for solvent-free synthesis of 2-naphthol azo dyes
A convenient, one-pot method for the synthesis of diazonium salt has been developed by the sequential diazotization of aromatic amines with NaNO2, polymer- supported periodic acid (PPIA) and 2-naphthole under solvent-free conditions at room temperature. By using this method, several types of aromatic amine, containing electron-withdrawing and electron-donating groups, were rapidly converted to ...
متن کاملZnO nanoparticles as an Efficient and Reusable Catalyst for Synthesis of Quinoxaline under Solvent Free Condition
1,2-Diketones have been reacted in one-pot method with 1,2-diamines at room temperature with ZnO nanoparticles as a catalyst. ZnO nanoparticles as an available and reusable catalyst is used for the synthesis of Quinoxalinein improved yields.
متن کاملPolymer/HIO4 : An efficient catalyst for solvent-free synthesis of 2-naphthol azo dyes
A convenient, one-pot method for the synthesis of diazonium salt has been developed by the sequential diazotization of aromatic amines with NaNO2, polymer- supported periodic acid (PPIA) and 2-naphthole under solvent-free conditions at room temperature. By using this method, several types of aromatic amine, containing electron-withdrawing and electron-donating groups, were rapidly converted to ...
متن کاملLi + Modified Nanoporous Na+ -Montmorillonite an Efficient Novel Catalytic System for Synthesis of Quinolines
A simple and efficient method for the synthesis of quinolines and polycyclic quinolines using Li+ modified nanoporous Na+-montmorillonite is described. This new nanocatalyst proceeds via Friedlander annulation under solvent-free conditions. It describes our observations about a trend of catalytic activity of Lithium cation in nanoporous Na+-montmorillonite. In this study, several types of 1,3-d...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
jundishapur journal of natural pharmaceutical productsجلد ۷، شماره ۲، صفحات ۶۱-۶۴
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023